Server-Side Rendering (SSR) is a process where web pages or web applications are generated on the server and sent to the browser as complete HTML pages. In contrast, with Client-Side Rendering (CSR), the user interface is built on the client-side by downloading JavaScript code and dynamically rendering the page.

During Server-Side Rendering, the application runs on the server, and the HTML file is prepared with the actual content of the page, including data from the database or other resources. The fully rendered HTML page is then sent to the browser, and the browser only needs to load the CSS and JavaScript required for interactivity. This allows users to see a fully rendered page immediately before JavaScript is executed.

The advantages of Server-Side Rendering are:

1. Improved initial loading performance: Since the server pre-renders and sends the content, users see a complete page immediately, reducing waiting times and improving user experience.

2. Search Engine Optimization (SEO) friendliness: Search engines can crawl and index the fully rendered HTML content, leading to better content visibility in search results.

3. Better accessibility: If JavaScript fails to load or execute properly, users can still see the page content as it was pre-rendered on the server.

The disadvantages of Server-Side Rendering are:

1. Increased server load: Rendering pages on the server requires additional resources and may increase server load.

2. Potentially longer loading times for interactions: Each interaction with the application may trigger a new server request, resulting in a slight delay as the server renders and sends the new page to the browser.

Server-Side Rendering is well-suited for content pages and applications where SEO and initial loading time are crucial. For complex, interactive applications, a combination of Server-Side Rendering for the initial page and Client-Side Rendering for interactive parts of the application (e.g., SPA) can be used to leverage the best aspects of both approaches.

Vue.js, often simply referred to as Vue, is a progressive, JavaScript-based open-source frontend framework used for building user interfaces and Single Page Applications (SPAs). It was developed by Evan You and first released in 2014. Vue.js is similar to Angular and React, but it stands out for its simple syntax, flexibility, and small size.

The key features of Vue.js include:

1. Component-based architecture: Vue.js allows creating reusable components, each with its own logic and presentation. These components can be composed in hierarchies to build complex user interfaces.

2. Declarative rendering: Vue.js uses a declarative syntax to define the UI based on the state (data). This makes UI development and maintenance easier.

3. Directives: Vue.js provides a variety of directives that extend HTML and can control interactions between users and the UI. Examples include v-if, v-for, v-bind, and v-on.

4. Reactivity: Vue.js implements reactive data binding, enabling changes in the data model to automatically update the UI representation.

5. Transitions and animations: Vue.js offers built-in support for adding transitions and animations to UI elements.

6. Routing: Vue.js supports routing to enable navigation between different views in an SPA.

Vue.js can be used either as a standalone library or integrated into larger projects. It has a growing developer community and is used in real projects by many companies. Vue.js is easy to learn and suitable for both small prototypes and large, complex applications. Due to its flexibility and performance, Vue.js is considered one of the leading frontend frameworks.

A Single Page Application (SPA) is a type of web application that consists of only one single HTML page. In contrast to traditional multi-page web applications, where each action loads a separate HTML page from the server, SPAs keep the main page unchanged throughout the entire usage of the application. Instead, data and content are dynamically loaded and updated as needed, without requiring a full page refresh.

The functioning of a Single Page Application relies on JavaScript frameworks like Angular, React, or Vue.js. These frameworks allow organizing the user interface into components and performing navigation and content updates within the application without the server needing to provide a new HTML page every time.

The benefits of SPAs include:

1. Fast user experience: Since SPAs are loaded only once and subsequently load only the necessary data, the application feels faster as users don't have to wait for page reloads.

2. Improved interactivity: SPAs enable a reactive user experience, as the user interface can respond quickly to user actions without reloading the entire page.

3. Reduced server traffic: SPAs minimize server traffic since only data, not the entire HTML page, is transmitted.

4. Native app-like experience: SPAs can be designed with responsiveness and touch gestures to provide a similar user experience to native mobile apps.

5. Easy development: With JavaScript frameworks, developing SPAs is more efficient as the application can be divided into individual components.

While SPAs offer many advantages, they also present some challenges, such as potentially longer initial loading times as the entire JavaScript codebase needs to be loaded. Additionally, SPAs are susceptible to SEO issues, as search engines may have difficulty indexing dynamically loaded content. Thus, specific SEO techniques like prerendering or server-side rendering (SSR) need to be applied to address these challenges.